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Brushing only reaches 25% of your mouth, and the germs left behind after brushing double every 1-2 hours. LISTERINE fights germs that cause plaque and gives a 3x deeper clean vs brushing alone. Used twice daily, LISTERINE provides 24-hour protection against plaque and lasting fresh breath confidence. LISTERINE is clinically proven to: ? Help prevent & reduce plaque, a major cause of gum disease ? Help fight bacteria between teeth ? Freshen breath ? Alcohol-free